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The primary route of drug distribution (direct to systemic circulation), is characterized by an initially slow rate of drug absorption and, if the is cleared rapidly, a relatively low concentration of drug in the plasma. This is followed by a rapid decrease in plasma drug concentration following clearance, an increase in concentration of metabolites, and a subsequent decrease following absorption in the gut [ 6 ].
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Duloxetine is widely prescribed in patients with irritable bowel syndrome to improve function in these patients [ 1 ]. In a study, 10 mg/day of lorazepam compared with 50 mg/day of
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The primary variables that contributed to the variance of study were duration
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The doses for dronabinol are in the range of 5.9-10.9 mg/day, while the doses for lamotrigine are 5.3-9.9 mg/day. The doses for duloxetine are in the range 10-55 mg/day, while.
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