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Price of generic tretinoin 0.35% and retinol 0.005% for the first time.) Tretinoin can cause erythema, pigmentation, peeling and itching; contact dermatitis; granuloma formation; and can trigger retinoid-induced phototoxicity. Patients should report their experience with use of retinoids to the FDA's MedWatch program. In an open-label phase III study of tretinoin in patients with moderate-to-severe Fitzpatrick skin disease, approximately 15% of patients reported adverse reactions, principally burning or stinging, pruritus, itching irritation, and pruritus. Topical retinoid products containing hydroxypinacolone, retinoic acid, tretinoin, or other retinoids have not been studied for treatment of hyperpigmentation. However, this product category contains sunscreens that cause sunburn, and the FDA will carefully follow information available and take appropriate action if the risk of serious adverse events (SAEs) increases. Please see ADVERSE REACTIONS under USE IN SPECIFIC POPULATIONS and PRECAUTIONS. Patient Counseling Information Advise the patient to read FDA-approved labeling (Medication Guide) and to read follow all instructions and warnings contained with it. Advise patients to read the Medication Guide and to discuss it with their healthcare provider. These products are not intended for use in women who are pregnant, lactating, trying to become have liver or kidney disease, heart disease. Consult a healthcare provider before using this product if any of the following conditions exist: a) a previous history of exposure to chemical irritants the eye, skin, or mucous membranes; b) a previous history of systemic toxicity; c) immunodepression; d) immunosuppression; e) a history of skin transplantation; f) immuno-suppressive drug therapy; g) chronic diseases requiring frequent drug injections; h) glaucoma; i) severe asthma or other breathing difficulty; j) severe eye irritation of unknown origin; k) skin rash with a history of contact sunlamps or other sources of sun-induced chemical irritants; l) chronic or recurrent infection; m) other conditions for which the prescribing physician has evaluated risks and benefits; n) the patient is unwilling or unable to make the required daily dosage changes; or o) the patient is unable to use the product due a physical limitation. Patients also should discuss the risks and benefits of treatment with their healthcare provider before making a decision to receive this drug, and notify the manufacturer should their physician change his/her opinion. Drug Interactions Drugs that interact with retinoids can cause eye redness, dryness, burning, pain, peeling, or itching. Tell your healthcare provider about all medications and any other supplements you take. Accidental overdose of retinoids can cause death. Use caution when combining retinoids and other medications or supplements when the possible interaction risk differs from other medications or supplements. If possible, ask your healthcare provider which medication(s) should be avoided if you are taking this product. This product is a prescription only as defined by the.

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